NATURAL SELECTION ON EDUCATIONAL ATTAINMENT DID NOT PRODUCE ALLELIC DIFFERENTIATION BETWEEN POPULATIONS

Only some days after the article of Wong (2018), and in line with this article, a study of Guo (2018) found that natural selection on „educational attainment” did not produce higher allelic differentiation than explained by drift, between AFR, EUR and EAS populations. Unfortunately, Guo (2018) did not test the allelic differentiation for IQ. Wong (2018) found a much higher SNP differentiation for IQ than for EDU in 1000 GENOMES.

Between 10 complex traits, Guo (2018) found SNP differentiation only on height, waist-to-hip ratio and schizophrenia.

In a recent article, Curtis (2018) sustained that polygenic risk score for schizophrenia could be more strongly associated with ancestry than with schizophrenia. Differences of POLY_SCZ between Africans and Europeans are ten fold higher than differences of POLY_SCZ between European schizophrenics and European healthy controls. But Wong (2018) found the lowest allelic differentiation for SCZ.

 

REFERENCES

Curtis, D. et al (2018) Polygenic risk score for schizophrenia is more strongly associated with ancestry than
with schizophrenia. bioRxiv doi: http://dx.doi.org/10.1101/287136 .

Guo, J. et al (2018) Global genetic differentiation of complex traits shaped by natural selection in humans. Nature Communications. DOI: 10.1038/s41467-018-04191-y

Wong, E.S. et al (2018) Evidence for stabilizing selection at pleiotropic loci for human complex traits. bioRxiv doi: http://dx.doi.org/10.1101/126888 .