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THE POLYGENIC RISK SCORE FOR SCHIZOPHRENIA PREDICTS THE MEASURED IQ OF EUROPEAN POPULATIONS BETTER THAN POLYGENIC SCORES FOR IQ AND EDUCATIONAL ATTAINMENT

Septembrie 29, 2017

I calculated the mean frequencies of 112 SNP that favor schizophrenia in European populations from 1000 GENOMES, and I found these frequencies better predict the measured IQ of populations than POLY_IQ and POLY_EDU:

POP     IQ     POLY_SCZ      POLY_IQ     POLY_EDU

FIN     101         0.2821             0.4621          0.5160

GBR   100         0.2887             0.4654          0.5060

CEU     99         0.2933             0.4747          0.5030

TSI       99          0.2965            0.4579          0.5130

IBS       97          0.2959            0.4535          0.5130

Furthermore, a simple empirical formula could predict the (genotypic) IQ of European populations in 1000 GENOMES:

IQ_POP = POLY_SCZ_GBR : POLY_SCZ_POP x 100

Here are the results: FIN=102.34, GBR=100, CEU=98.43, TSI=97.37, IBS=97.57

Although, a very recent study (Alloza, 2017) found a correlation of 0.508 between intelligence and POLY_SCZ at individual level. At population level, the correlation seems be even higher.

 

Also, POLY_SCZ on 122 SNP predicts the measured IQ of super-populations better than other polygenic scores:

POP     IQ      POLY_SCZ     POLY_IQ     POLY_EDU

AFR     69         0.3040              0.4714          0.4804

SAS      82         0.2926              0.4439          0.5038

AMR    85         0.2915              0.4515          0.4890

EUR     99         0.2886              0.4627          0.5102

EAS    104         0.2776              0.5129          0.5234

 

REFERENCES

Alloza, C. et al (2017) Central and non-central networks, cognition, clinical symptoms, and polygenic risk scores in schizophrenia. Human Brain Mapping doi: 10.1002/hbm.23798.

Ohi, K. et al (2017) Variability of 128 schizophrenia-associated gene variants
across distinct ethnic populations. Transl Psychiatry 7, e988; doi:10.1038/tp.2016.260

Okbay, A. et al. (2016). Genome-wide association study identifies 74 loci associated with educational attainment. Nature 533: 539-542.

Piffer, D. (2016). Polygenic selection on educational attainment: a replication. https://figshare.com/article/Polygenic_selection_on_educational_attainment_a_replication/3381439

Piffer, D. (2017)  2017 Intelligence GWAS: Group-level polygenic scores http://rpubs.com/Daxide/279148

Ripke, S. et al (2014) Biological Insights From 108 Schizophrenia-Associated Genetic Loci. Nature 511(7510): 421-427 doi:  10.1038/nature13595

Sniekers, S. et al (2017) Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nature Genetics doi:10.1038/ng.3869

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